diff --git a/config.mak.uname b/config.mak.uname
index 19ce2f296a..b71688eeb7 100644
--- a/config.mak.uname
+++ b/config.mak.uname
@@ -576,13 +576,21 @@ else
 	ifneq ($(shell expr "$(uname_R)" : '1\.'),2)
 		# MSys2
 		prefix = /usr/
+		# Enable DEP
+		BASIC_LDFLAGS += -Wl,--nxcompat
+		# Enable ASLR (unless debugging)
+		ifneq (,$(findstring -O,$(filter-out -O0 -Og,$(CFLAGS))))
+			BASIC_LDFLAGS += -Wl,--dynamicbase
+		endif
 		ifeq (MINGW32,$(MSYSTEM))
 			prefix = /mingw32
 			HOST_CPU = i686
+			BASIC_LDFLAGS += -Wl,--pic-executable,-e,_mainCRTStartup
 		endif
 		ifeq (MINGW64,$(MSYSTEM))
 			prefix = /mingw64
 			HOST_CPU = x86_64
+			BASIC_LDFLAGS += -Wl,--pic-executable,-e,mainCRTStartup
 		else
 			COMPAT_CFLAGS += -D_USE_32BIT_TIME_T
 			BASIC_LDFLAGS += -Wl,--large-address-aware