diff --git a/doc/guix.texi b/doc/guix.texi
index 12ecc1b952..6e867839a4 100644
--- a/doc/guix.texi
+++ b/doc/guix.texi
@@ -4362,7 +4362,8 @@ nothing and exit immediately.
 @item --delete-generations[=@var{duration}]
 @itemx -d [@var{duration}]
 Before starting the garbage collection process, delete all the generations
-older than @var{duration}, for all the user profiles; when run as root, this
+older than @var{duration}, for all the user profiles and home environment
+generations; when run as root, this
 applies to all the profiles @emph{of all the users}.
 
 For example, this command deletes all the generations of all your profiles
diff --git a/guix/scripts/gc.scm b/guix/scripts/gc.scm
index 043273f491..65cd4bdf8b 100644
--- a/guix/scripts/gc.scm
+++ b/guix/scripts/gc.scm
@@ -1,5 +1,5 @@
 ;;; GNU Guix --- Functional package management for GNU
-;;; Copyright © 2012, 2013, 2015, 2016, 2017, 2018, 2019, 2020 Ludovic Courtès <ludo@gnu.org>
+;;; Copyright © 2012-2013, 2015-2020, 2022 Ludovic Courtès <ludo@gnu.org>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -26,6 +26,7 @@
                                 profile-generations
                                 generation-number)
   #:autoload   (guix scripts package) (delete-generations)
+  #:autoload   (gnu home) (home-generation-base)
   #:use-module (ice-9 match)
   #:use-module (ice-9 regex)
   #:use-module (srfi srfi-1)
@@ -260,7 +261,8 @@ is deprecated; use '-D'~%"))
                      (filter-map (lambda (root)
                                    (and (or (zero? (getuid))
                                             (user-owned? root))
-                                        (generation-profile root)))
+                                        (or (generation-profile root)
+                                            (home-generation-base root))))
                                  (gc-roots)))))
       (for-each (lambda (profile)
                   (delete-old-generations store profile pattern))
diff --git a/guix/self.scm b/guix/self.scm
index d1ccec8a49..fc80e78804 100644
--- a/guix/self.scm
+++ b/guix/self.scm
@@ -929,6 +929,7 @@ itself."
                            (('guix 'scripts 'deploy) #t)
                            (('guix 'scripts 'home . _) #t)
                            (('guix 'scripts 'import . _) #t)
+                           (('guix 'scripts 'gc) #t) ;autoloads (gnu home)
                            (('guix 'pack) #t)
                            (_ #f))
                          (scheme-modules* source "guix/scripts"))